C-Reactive Protein (CRP) is the bestknown among the acute-phase proteins, the concentration of which increases in response to inflammation, postoperative conditions or tissue damage. CRP is normally present in low concentration (<5 mg/L) but increases rapidly during the acute inflammatory process with values increasing up to 500 mg/L during bacterial infections. The level of CRP can be detected 6 hours after inflammation starts reaching a peak at 48 hours. The determination of CRP represents a useful laboratory test for the detection of acute infection and for monitoring of inflammation in acute rheumatic and gastrointestinal diseases. In recent years, studies have shown that in apparently healthy individuals a direct correlation between the level of CRP and the risk of developing coronary heart disease (CHD) exists. CRP has also been reported as a potential marker for monitoring Statin therapy.