Simultaneous LC‑MS/MS measurement of six urinary oxidative stress biomarkers targeting DNA/RNA, lipids and proteins.
Overview
Oxidative stress is increasingly recognized as a key contributor to cardiovascular, metabolic, oncologic and inflammatory diseases, yet routine assessment often relies on single‑analyte, low‑specificity assays. The new LC‑MS/MS panel developed by Eureka Lab Division enables laboratories to quantify six urinary biomarkers of oxidative stress (2‑dG, 8‑OHdG, 8‑OHGuo, 8‑iso‑PGF2α, DiY and 3‑NT).in a single run, providing a comprehensive and non‑invasive picture of oxidative damage across multiple biological targets.
Why this panel matters for your lab
- Six urinary biomarkers in one LC‑MS/MS panel covering DNA/RNA, lipid and protein oxidation, help consolidate multiple tests into a single, standardized workflow
- High analytical performance, with broad linear range (up to 450–500 ng/mL) and low limits of quantification for all markers, supports confident result interpretation across a wide range of routine samples.
- Greater specificity and standardization than conventional immunoassays or colorimetric tests help reduce variability and support more robust decision‑making in oxidative stress‑related studies and applications.
Analytical performance
- Linearity: up to 450–500 ng/mL for almost all analytes
- LOQ: 1.5–2.5 ng/mL for most analytes (11.1 ng/mL for DiY)
From data to practical value
The OxiStress Urine kit offers a ready‑to‑implementLC‑MS/MS solution for multi‑marker monitoring of oxidative stress in urine, supporting both sports medicine and check‑up/wellness testing. By integrating six complementary biomarkers into a single panel, the assay helps laboratories generate more informative data on oxidative damage while optimizing time, sample volume and resources.
For full methodological details and chromatographic data, the complete scientific poster is available for download.