As Sentinel Diagnostics we are constantly working from the beginning of the COVID-19 pandemia providing high quality test for SARS-CoV-2 detection.
Recently new virus variants appeared, such as the UK variant (B.1.1.7), the South African variant (B.1.351), and the Brazilian variant (P.1). This raised concerns regarding their potential increased virulence and resistance to neutralizing Ab. Some alarms were also raised regarding the capacity of actual NAT test to detect these new mutants.
We are constantly monitoring the effectiveness of our NAT test for the detection of COVID-19 by verifying that variant-defining mutant loci does not fall within primers/probes annealing regions.
We have excluded that the mutations characterizing the UK variant (B.1.1.7), the South African variant (B.1.351), and the Brazilian variant (P.1) interest the primers/probes annealing regions used in our STAT-NAT® and SENTI-GENE® kits.
From this standpoint, our STAT-NAT® and SENTI-GENE® kits should maintain their analytical and clinical performances and fully preserve the capability to detect these variants.